The Twins' top prospect went 4-for-5 with three doubles, two RBIs and a run scored Friday night, leading the Class A Beloit Snappers to a 13-3 romp over the South Bend Silver Hawks.
Sano raised his average 53 points to .314, moving him above the .300 line for the first time this season. He moved into a tie for the Midwest League lead with 10 extra-base hits -- six homers, three doubles and a triple -- in 15 games.
Although Sano has spent most of the opening month as the Snappers' cleanup hitter, he made his fourth start of the year in the third spot in the lineup on Friday.
"I felt great at the plate today, I was very concentrated," Sano said through a translator. "I feel better hitting in the three-hole, and I was just looking to make contact."
Sano began his night with a walk, giving him a league-leading 12 after he took only 23 free passes in 66 games last season at Rookie-level Elizabethton. He doubled in each of his next two at-bats, knocking in a run with the second.
The native of the Dominican Republic struck out leading off the seventh, but he ended the night by singling to begin the eighth and stroking another double in the ninth.
"I feel great, I'm really happy with how the season is going so far," Sano said. "I'm working hard, both physically and mentally to keep improving."
In addition to walks, Sano leads the Class A league with 18 RBIs, a .765 slugging percentage and a 1.218 OPS. He said one of his aims this season was to take a more patient approach at the plate.
"I wanted to focused more on getting walks this season because last year, I didn't do that," the 18-year-old third baseman said. "Right now, I've been able to see more pitches and am getting more adjusted to that. I would like to get a bunch of walks and have a high on-base percentage."
Off the field, Sano is the subject of the documentary Pelotero, which follows him and countryman Jean Carlos Batista through the process of signing with Major League teams. The film, produced by Red Sox manager Bobby Valentine, is set for theatrical release this year.
"I feel really good that some people are taking an interest in making a film about my life," Sano said. "I didn't feel any pressure around the cameras."
Jonathan Goncalves also had a solid game for the Snappers with a triple, two walks and three RBIs. Adam Bryant scored three times, while Eddie Rosario and JaDamion Williams both plated a pair of runs.
Beloit starter Jason Wheeler (1-0), an eighth-round pick in last year's Draft, earned his first professional win after allowing two runs -- one earned -- on four hits over six innings.